Publications

 

1: Pokrass MJ, Ryan KA, Xin T, Pielstick B, Timp W, Greco V, Regot S. Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo. Developmental Cell. 2020 Nov 9;55(3):328-340.e5. doi: 10.1016/j.devcel.2020.09.013. 

2: Aikin TJ, Peterson AF, Pokrass MJ, Clark HR, Regot S. MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression. eLife. 2020 Sep 17;9:e60541. doi: 10.7554/eLife.60541. 

3: Wu CC, Peterson A, Zinshteyn B, Regot S, Green R. Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate. Cell. 2020 Jul 23;182(2):404-416.e14. doi: 10.1016/j.cell.2020.06.006. 

4: Yang HW, Cappell SD, Jaimovich A, Liu C, Chung M, Daigh LH, Pack LR, Fan Y, Regot S, Covert M, Meyer T. Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation. eLife. 2020 Apr 7;9:e44571. doi: 10.7554/eLife.44571. 

5: Sung MH, Regot S. Editorial: Understanding Immunobiology Through the Specificity of NF-κB. Front Immunol. 2020 Jan 30;11:59. doi: 10.3389/fimmu.2020.00059. 

6: DeFelice MM*, Clark HR*, Hughey JJ, Maayan I, Kudo T, Gutschow MV, Covert MW, Regot S. NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop. Sci Signal. 2019 Apr 30;12(579):eaau3568. doi: 10.1126/scisignal.aau3568. 

7: Kudo T, Jeknić S, Macklin DN, Akhter S, Hughey JJ, Regot S, Covert MW. Live-cell measurements of kinase activity in single cells using translocation reporters. Nat Protoc. 2018 Jan;13(1):155-169. doi: 10.1038/nprot.2017.128. 

8: Yoon KJ, Ringeling FR, Vissers C, Jacob F, Pokrass M, Jimenez-Cyrus D, Su Y, Kim NS, Zhu Y, Zheng L, Kim S, Wang X, Doré LC, Jin P, Regot S, Zhuang X, Canzar S, He C, Ming GL, Song H. Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation. Cell. 2017 Nov 2;171(4):877-889.e17. doi: 10.1016/j.cell.2017.09.003. 

9: de la Cova C, Townley R, Regot S*, Greenwald I*. A Real-Time Biosensor for ERK Activity Reveals Signaling Dynamics during C. elegans Cell Fate Specification. Developmental Cell. 2017 Sep 11;42(5):542-553.e4. doi: 10.1016/j.devcel.2017.07.014.

10: Sharifian H, Lampert F, Stojanovski K, Regot S, Vaga S, Buser R, Lee SS, Koeppl H, Posas F, Pelet S, Peter M. Parallel feedback loops control the basal activity of the HOG MAPK signaling cascade. Integr Biol. 2015 Apr;7(4):412-22. doi: 10.1039/c4ib00299g.

11: Regot S, Hughey JJ, Bajar BT, Carrasco S, Covert MW. High-sensitivity measurements of multiple kinase activities in live single cells. Cell. 2014 Jun 19;157(7):1724-34. doi: 10.1016/j.cell.2014.04.039. PubMed PMID: 24949979; PubMed Central PMCID: PMC4097317.

12: Sanghvi JC, Regot S, Carrasco S, Karr JR, Gutschow MV, Bolival B Jr, Covert MW. Accelerated discovery via a whole-cell model. Nat Methods. 2013 Dec;10(12):1192-5. doi: 10.1038/nmeth.2724. Epub 2013 Nov 3. PubMed PMID: 24185838; PubMed Central PMCID: PMC3856890.

13: Regot S, de Nadal E, Rodríguez-Navarro S, González-Novo A, Pérez-Fernandez J, Gadal O, Seisenbacher G, Ammerer G, Posas F. The Hog1 stress-activated protein kinase targets nucleoporins to control mRNA export upon stress. J Biol Chem. 2013 Jun 14;288(24):17384-98. doi: 10.1074/jbc.M112.444042. Epub 2013 May 3. PubMed PMID: 23645671; PubMed Central PMCID: PMC3682539.

14: Regot S, Macia J, Conde N, Furukawa K, Kjellén J, Peeters T, Hohmann S, de Nadal E, Posas F, Solé R. Distributed biological computation with multicellular engineered networks. Nature. 2011 Jan 13;469(7329):207-11. doi: 10.1038/nature09679. Epub 2010 Dec 8. PubMed PMID: 21150900.

15: Warringer J, Hult M, Regot S, Posas F, Sunnerhagen P. The HOG pathway dictates the short-term translational response after hyperosmotic shock. Mol Biol Cell. 2010 Sep 1;21(17):3080-92. doi: 10.1091/mbc.E10-01-0006. Epub 2010 Jun 29. PubMed PMID: 20587780; PubMed Central PMCID: PMC2930000.

16: Macia J*, Regot S*, Peeters T, Conde N, Solé R, Posas F. Dynamic signaling in the Hog1 MAPK pathway relies on high basal signal transduction. Sci Signal. 2009 Mar 24;2(63):ra13. doi: 10.1126/scisignal.2000056. PubMed PMID: 19318625.