I have always been fascinated by how molecules are used to monitor cellular or environmental parameters, relay information, and execute appropriate responses. As a graduate student I used yeast as a model to study osmostress response. In the process I learned about MAP Kinases and the astonishing amount of cell-to-cell variation that governs all aspects of cell biology. As a postdoc I developed tools for single cell analysis of signaling dynamics in mammalian cells. Now I am fortunate to continue exploring the most fundamental principles of cell signaling at JHU surrounded by talented young scientists. My current goal is to understand how molecules and molecular complexes are organized in space and time in live cells to coordinate cellular adaptation.